Science, Technology

The Combination of Alcohol and Gut Fungus May Harm Your Liver

The Combination of Alcohol and Gut Fungus May Harm Your Liver

Despite certain health claims attributed to alcohol, such as wine, alcohol consumption remains questionable. In fact, more and more studies do not indicate that drinking alcohol can cause more harm than good. For example, the new study, published in the journal Clinical Investigation, shows that a combination of bowel fungus and chronic liver disease can be fatal for people with alcohol-related liver disease.

The study also indicates that some antifungal compounds such as amphotericin B may be able to control the progression of progression of alcohol-related liver disease, but in addition to alcohol withdrawal, there are no specific treatments to reduce the severity of liver disease Associated with alcohol. However, lead author Bernd Schnabl of California at San Diego University explains that they could slow the progression of alcoholic liver disease by manipulating the balance of fungal species in a patient’s intestine. The team carried out tests on a mouse model and found that they have mushrooms bloomed in the intestines of mice with chronic exposure to alcohol. Chronic inflammation kills liver cells and ultimately paves the way for alcoholic liver disease. However, researchers were able to protect mice against alcohol-induced liver disease by treatment with amphotericin B. The antifungal mice received an oral type of amphotericin B that is not absorbed into the bloodstream, but amphotericin B by mouth is not FDA – approved for human use. Amphotericin B IV B is approved by the FDA for the treatment of serious fungal infections and can cause side effects such as stomach, bone, muscle or joint pain and shortness of breath.

Compared to untreated mice, mice with alcohol-related liver disease receiving amphotericin B had lower levels of liver injury and fat accumulation. These results were determined by measuring plasma concentrations of a liver enzyme called alanine aminotransferase (reduced by approximately 55%) and hepatic triglyceride (reduced by about 21%).
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The team also compared the fungus in the feces of eight healthy people and 20 people with chronic alcohol and various stages of liver disease. They found that healthy people have a high diversity of fungi that live in their intestines compared to alcohol-addicted patients. The team of experts also found a correlation between fungi and disease severity in a separate group of 27 patients with alcohol-related liver disease. After five years of analysis, 77% of low-cluster mushrooms survived, versus 36% of the fungi group.

Because the results were so positive in mice, researchers would now test amphotericin B in patients with alcohol-related liver disease to increase their value. Alcohol-related liver disease can be of many types, such as fatty liver, alcoholic hepatitis, or cirrhosis of the liver. In most cases, these diseases damage or destroy liver cells. The liver works to distribute the chemicals in alcohol so they can be eliminated from your body. However, it can be damaged and overloaded if you drink more alcohol than you can handle. Therefore, it is very important to limit alcohol intake and not go to the seashore.

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